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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objective To determine the correlation between the ovarian masses' histopathology and circulating tumor cells (CTCs). Background Ovarian cancer is the most frequent cause of death among gynecological cancer cases worldwide. Patients and methods This is a prospective study that was carried on 66 patients in Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University and Centre of Excellence in Cancer Research between December 2018 and March 2021. The patients included in the study were with a previous diagnosis of suspected ovarian malignancy depending on history, ultrasound criteria, and tumor markers and prepared for exploratory laparotomy for debulking surgery. For all patients, detailed history taking, complete clinical examination, abdomen and pelvic ultrasound, cancer antigen 125 and risk of malignancy index (RMI) were done. Results Our results reported that there was a highly statistically significant positive correlation between CTCs and RMI in the studied patients and a highly statistically significant positive correlation between CTCs and cancer antigen 125 in the studied patients. There was a highly statistically significant positive correlation between CTCs and International Federation of Gynaecology and Obstetrics (FIGO) staging in the studied patients; however, no statistically significant correlation between RMI and FIGO staging was found in the studied patients. There was a statistically significant difference (P < 0.05) between the studied cases (CTCs) regarding histopathological grades. Conclusion CTCs allow differentiation between malignant and nonmalignant ovarian masses, and CTCs are well correlated with the FIGO stage.

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