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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective This study aimed to investigate the relationship between vitamin D levels and health-related quality of life in maintenance hemodialysis patients. Background Several conditions associated with vitamin D deficiency in end-stage renal disease and hemodialysis patients can indirectly or directly affect the quality of life. Patients and methods The present study included 85 end-stage renal disease patients, subdivided into group I, which included 64 vitamin D-deficient patients, and group II, which included 21 vitamin (D)-efficient patients. Every participant was subjected to sociodemographic, clinical, and laboratory evaluations; each patient underwent a full general assessment of health-related quality of life by the Arabic version of the kidney disease quality of life short-form 1.3” questionnaire and measurement of serum 25(OH)D by an enzyme-linked immunosorbent assay. Results The mean 25(OH)D levels were 15.7 ± 6.40 and 36.6 ± 5.99 ng/ml for the vitamin D-deficient group and -efficient group, respectively. The only factor independently associated with symptoms was serum 25(OH)D level (P = 0.044). Sex (female) and vitamin D levels were independent risk factors with the effect of kidney disease (P = 0.001). Independent risk factors associated with the burden of kidney disease subscale were comorbidity index and serum 25(OH)D levels (P = 0.015, 0.023, and 0.001, respectively). Serum 25(OH)D and age were independently associated with the physical component summary (P = 0.001 and 0.016). The independently associated factor with the mental component summary was serum 25(OH)D and albumin levels (P = 0.001 and 0.016). Conclusion Lower serum vitamin D levels were negatively associated with all subscales of quality of life in maintenance hemodialysis patients.

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