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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objectives The work aimed to evaluate the role of melatonin in erectile dysfunction (ED) by measuring its level in the serum of these patients and correlating its level with the clinical data. Background One common issue is ED. It is the persistent inability to obtain or maintain a sufficient penile erection for satisfactory sexual performance. One of the hormones secreted from the pineal gland is melatonin. It has antioxidative and antiinflammatory effects. It plays a role in erectile function. In the etiology of ED, oxidative stress is an essential factor, and promising results have been obtained with melatonin treatment in many experimental models. Patients and methods This case–control study included 60 patients with ED and 30 age-matched healthy controls. The serum melatonin level was measured in all participants by enzyme-linked immunosorbent assay. Results The study results revealed a significant difference between patients with ED and normal persons regarding mean serum melatonin level. It was lower in cases than controls (2.11 ± 1.73 vs. 5.69 ± 4.33 ng/l), with P value of 0.001. There was no significant difference among the three ED classes in the levels of serum melatonin. There was no significant relation between melatonin level and diabetes, hypertension, hepatitis C virus, and smoking (P > 0.05). Conclusion There has been a significant association between ED and low levels of serum melatonin. This relationship indicates that in the etiology of ED, melatonin deficiency may be of significance.

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