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Subject Area

Orthopedic Surgery

Article Type

Original Study

Abstract

Objective The aim was to estimate serum level of apolipoprotein E (Apo E) in patients with temporal lobe epilepsy (TLE) and to investigate the association between Apo E and cognitive functions in patients with TLE. Background There is a relation between Apo E and TLE, which has led to increased attention for examination. Apo E may exacerbate epilepsy and promote memory impairment in patients with long-standing TLE. Patients and methods A total of 40 patients with TLE and 40 normal participants were included. Interictal electroencephalogram and magnetic resonance imaging were done. Brain cognitive assessment was done using minimental state examination and Addenbrooke's cognitive examination revised (ACE-R). Serum Apo E was done using enzyme-linked immunosorbent assay technique. Results Minimental state examination and ACE-R scores were significantly less in the patients with TLE compared with the controls (P < 0.001 and < 0.001). Serum Apo E levels were significantly higher in patients with TLE compared with the control group (P < 0.001). Serum Apo E was significantly correlated with total ACE-R, as well as memory, verbal fluency, and visuospatial subsets of ACE-R (P < 0.001, <0.001, <0.001, and < 0.001, respectively). Conclusion There is a cognitive impairment in patients with TLE especially for memory, verbal fluency, and visuospatial activity. Serum Apo E was associated with cognitive impairment in TLE, which may suggest its possible role in cognitive impairment in patients with TLE.

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