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Subject Area

Ophthalmology

Article Type

Original Study

Abstract

Objectives This study aimed to evaluate the immunohistochemical expression of Ezrin in various histopathological types of colorectal carcinoma, and to examine its association with various clinicopathological features and so evaluate its prognostic significance. Background Colorectal cancer is considered one of the most common cancers worldwide, it developed because of the cumulative effect of sequential genetic alterations. Thus, more extensive studies are needed to demonstrate the molecular mechanism of colorectal cancer initiation and progression. Ezrin gene has an important role in cell movement, migration, mitosis, and other physiological functions, and is involved in maintaining cell structure and cell motility. Its expression correlates with many human malignancies. Patients and methods Ezrin antibody immunostaining was performed using the avidin–biotin–peroxidase complex method in 204 cases of primary colorectal carcinomas, including 118 (57.8%) cases of adenocarcinoma, 56 (27.5%) cases of a mucoid carcinoma, and 30 (14.7%) cases of signet ring cell carcinoma. Results Cytoplasmic Ezrin expression was significantly higher in lymph-node-positive cases (P < 0.0001), in cases with lymph–vascular invasion (P = 0.037), and with advanced tumor stage (P < 0.0001). Conclusion High Ezrin expression is considered a poor prognostic factor for colorectal adenocarcinoma.

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