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Subject Area

Ophthalmology

Article Type

Original Study

Abstract

Objective To determine the expression of cell cycle protein cyclin D1 in urothelial carcinoma and to correlate it with clinicopathological parameters and overall survival. Background Dysregulation of the cell cycle is a key mechanism for the occurrence of various types of tumors, including urinary bladder carcinoma (UBC). Cyclin D1 critically targets the proliferative signals and has been implicated in progression of UBC. Materials and methods This retrospective control study was conducted on 80 cases of urothelial carcinoma, which were classified according to muscularis propria invasion into 50 cases of muscle invasive bladder carcinoma and 30 cases of non-muscle-invasive bladder carcinoma (NMIBC). Immunohistochemistry staining for cyclin D1 antibody was done for all cases. Results Cyclin D1 was positive in 61 (76.2%) of 80 urothelial carcinoma cases. Cyclin D1 expression is significantly associated with early stage group (P = 0.031), early lymph node staging (P = 0.001), and absent perineural invasion (P = 0.037) in infiltrating urothelial carcinoma. NMIBC cases showed significant association with cyclin D1 expression (P = 0.025) and strong intensity (P = 0.018). Moreover, high immunoreactive score of cyclin D1 was significantly associated with NMIBC group (P = 0.001). Conclusion Cyclin D1 expression implies a good prognostic effect in UBC, as an inverse correlation between cyclin D1 expression and poor prognostic pathologic features (muscle invasive bladder carcinoma, advanced stage, perineural invasion and lymph node involvement) was displayed in the current study.

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