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Subject Area

Cardiac Surgery

Article Type

Original Study

Abstract

Objective To screen neonates with hyperbilirubinemia who received phototherapy to determine the effect of phototherapy on the serum magnesium level. Background Hyperbilirubinemia is one of the most prevalent problems in neonates. Phototherapy remains the main primary management in neonatal jaundice. However, it has many adverse effects, and hypomagnesemia is one of them. Patients and methods A prospective hospital-based comparative study was conducted on 70 eligible neonates admitted in Neonatal Intensive Care Units of Menoufia University Hospital receiving phototherapy from May 2019 to February 2020. Serum bilirubin and magnesium (total and ionized) were determined before starting phototherapy, and it was considered as control. Then serum bilirubin and magnesium were measured after 48 h of phototherapy and after termination of phototherapy. The plasma magnesium level was measured spectrophotometrically using ready-for-use kit supplied by Quimica Clinica Aplicada S.A. Company. Results The total serum magnesium level before phototherapy was 2.7 ± 0.3, 2.1 ± 0.30 mg/dl 48 h after phototherapy, and 1.85 ± 0.28 mg/dl after termination of phototherapy. Serum ionized magnesium level before phototherapy was 0.58 ± 0.02, 0.53 ± 0.02 mmol/l 48 h after phototherapy, and 0.51 ± 0.01 mmol/l after termination of phototherapy. So, there was a significant decrease in serum magnesium level (total and ionized) after phototherapy. Conclusion Our study concluded that there was a significant negative correlation between the duration of phototherapy and serum magnesium level (total and ionized).

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