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Subject Area

Anesthesiology and Intensive Care

Article Type

Original Study

Abstract

Objectives In this study, we evaluated free thyroxine and thyroid-stimulating hormone (TSH) concentrations between normal children and those with obesity and possible correlations between BMI and these markers. Background Evaluation of thyroid function determines the cause of obesity in children and adolescents. In children with obesity, TSH and thyroid hormone concentrations are shown to be high, which is accompanied by weight gain, increased cholesterol levels, and impaired growth velocity. Patients and methods This study was done on 200 Egyptian children and adolescents in the age of 5–18 years, comprising 71 overweight, 29 obese children and adolescents, and 100 nonobese children and adolescents. Results Our study revealed statistically significant differences between the studied patients regarding age, weight, height, BMI, waist circumference, hip circumference, and waist-to-hip ratio, as well as serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein-cholesterol (LDL-c), fasting and random blood sugar, and hemoglobin A1C (HbA1C). There is a significant positive correlation between serum TSH of the studied patients and body weight, BMI, waist and hip circumferences, waist-to-hip ratio, serum triglycerides, total cholesterol, LDL-c, fasting and random blood sugar, and HbA1C. Moreover, there is a significant positive correlation between BMI of the studied patients and body weight, waist and hip circumferences, waist-to-hip ratio, serum triglycerides, total cholesterol, LDL-c, fasting and random blood sugar, and HbA1C. Total cholesterol and hip circumference were significantly associated with TSH. Conclusion TSH could contribute to increases in total cholesterol, LDL-c, and triglycerides, but not high-density lipoprotein, irrespective of obesity.

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