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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective This study was to assess the association between psoriasis and metabolic syndrome (MBS) and to determine if there is an association between psoriasis severity and MBS. Background Background: Psoriasis is a chronic inflammatory disease that affects not only the skin but also other organs. Genetic factors play an important role in individual predisposition. Lately, a positive association has been confirmed between psoriasis and MBS, in Western as well as in Middle Eastern countries. Patients and methods This case–control study was conducted at the Dermatology, Andrology and Sexually Transmitted Disease and Medical Biochemistry and Molecular Biology Departments, Faculty of Medicine, Menoufia University. It included 120 patients: 60 psoriatic patients and 60 age-matched and gender-matched healthy controls. Patients were collected from Dermatology Outpatient Clinics, Menoufia University Hospitals. Clinical, biometric, and necessary laboratory evaluations were performed. Statistical analysis was performed by using the Statistical Package for the Social Sciences (SPSS version 16.0). Results The patients with psoriasis were two times more likely to have MBS as compared with controls (38.3 vs 18.0%, P < 0.001) with an odds ratio of 2.4. All components of MBS were more prevalent in psoriasis patients than in controls. The psoriasis area severity index score was greater in patients with MBS than those without MBS (10.5 11.5 vs 7.0 8.1, P = 0.05). MBS prevalence tended to be higher in the inverse type than in others (52.2 vs 32.3%; P = 0.06) and in patients with nail pitting versus those without (45.3 vs 28.2%; P = 0.03). Conclusion This study concluded that there is an association between psoriasis and MBS.

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