•  
  •  
 

Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives The aim of this study was to investigate the role of serum paraoxonase 1 (PON1) activity in the antioxidant system defect in alopecia areata (AA), which may help in the management of the disease. Background AA is an autoimmune disease of the hair follicle, resulting in acute or chronic patches of hair loss, total hair loss of the scalp (alopecia totalis), or complete hair loss of entire body and scalp (alopecia universalis). It is a disease with significant effect on health-related quality of life, in particular to the domains of role emotional, mental health, and vitality. Patients and methods This case–control study was conducted at Dermatology, Andrology, and Sexual Transmitted Diseases and Medical Biochemistry and Molecular Biology Departments, Faculty of Medicine, Menoufia University. It included 50 participants: 25 patients with AA and 25 age-matched and sex-matched healthy controls. Results There was a significant statistical decrease in serum PON1 level in patients compared with control (P < 0.001). There was a nonsignificant positive correlation between serum PON1 and each of age (P = 0.445), duration of disease (P = 0.886), total cholesterol (P = 0.769), and low-density lipoprotein cholesterol (P = 0.867), whereas a nonsignificant negative correlation existed with serum triglycerides (P = 0.815) and high-density lipoprotein cholesterol (P = 0.185). Conclusion This study concluded that there is an association between oxidant/antioxidant imbalance and AA.

Download

Share

COinS