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Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Aim and objectives To assess the effectiveness of sentinel lymph node biopsy in evaluation of the axillary status after neoadjuvant chemotherapy in breast cancer cases in comparison with standard axillary dissection. Background Breast carcinoma is the commonest malignant tumor in women. In Egypt, it accounts for ~25.5% of all women cases. In Egyptian women, the average age incidence is ~44.1 years, being more common in nullipara. The standard axillary lymph node dissection done in patients with breast cancer has many comorbidities that affect the patients' quality of life. Patients and methods The present cross-sectional study was conducted at Menoufia University Hospital on 50 patients with breast cancer who underwent sentinel lymph node biopsy after having neoadjuvant chemotherapy between January 2019 and February 2020. Results Sentinel lymph node biopsy after neoadjuvant chemotherapy has acceptable false-negative results, is less invasive than a complete or level one and two axillary dissection, and has lower both morbidity and cost. Conclusion Sentinel lymph node was successfully identified in 42 patients, with an identification rate of 84% (42/50). Of the eight cases in which sentinel lymph nodes was not identified, three had positive axillary lymph node deposits.

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