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Subject Area

Radiology and Imaging Sciences

Article Type

Original Study

Abstract

Objective To evaluate the role of Beclin 1 in basal cell carcinoma (BCC). Background BCC is the most common kind of skin cancer with increased incidence. Autophagy is considered an intracellular homeostatic pathway that is related to cancer and other diseases. Beclin 1 is a specific marker for autophagy. Patients and methods This An Ambidirectional Cohort Study was conducted on 77 cases with BCC and 20 age-matched and sex-matched apparently healthy participants. All sections were immunohistochemical stained for Beclin 1 antibody. Results Significant absolute Beclin 1 cytoplasmic localization in epidermis and dermis of control group was noted, whereas in BCC, most cases showed nucleocytoplasmic Beclin 1 expression in epithelial cells and surrounding stroma (P > 0.001 for both). High Beclin 1 H score and H score category of epithelium and stroma were significantly noted in BCC in comparison with control groups (P > 0.001 for both). There were significant associations between higher Beclin 1 stromal H score and noduloulcerative clinical presentation and adenoid variant of BCC (P = 0.001 and 0.02, respectively). Moreover, there was a positive correlation between Beclin 1 stromal H score and size of BCC. Conclusion Overexpression and nuclear localization of Beclin 1 could play a tumor-promoting role in pathogenesis of BCC.

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