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Subject Area

Cardiology and Vascular Medicine

Article Type

Original Study

Abstract

Objective To study and evaluate the role of both serum immunoglobulin E (IgE) and soluble E-selectin in patients with atopic dermatitis (AD). Background AD is a chronic inflammatory skin disease that is characterized by intense itching and recurrent eczematous lesions. Although it most often starts in infancy. It is also highly prevalent in adults. Assessment of maintenance of AD could be related to serum IgE and soluble E-selectin. Treatment of AD remains a challenge. Patients and methods This case–control study was performed for 40 patients who were age-matched and sex-matched with 20 healthy control cases. The patient group was subdivided into two groups according to their severity. The sample comprised 28 men and 32 women. Their ages ranged between 3 and 28 years. Results There was significant statistical differences between the two studied patient groups and the control group regarding total IgE and E-selectin serum levels that were higher in the patient group than the control one. There was also significant statistical increase in the level of serum IgE and soluble E-selectin in severe AD patients compared with mild cases. Conclusion There was a positive association between serum IgE, soluble E-selectin, and AD in general and also with severity. So it may be used as a marker for AD.

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