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Subject Area

Clinical Pharmacology

Article Type

Original Study

Abstract

Background Dry eye is the most common complication after laser in-situ keratomileusis (LASIK). Anterior segment optical coherence tomography (AS-OCT) is a noninvasive and quick clinical tool for the evaluation of a tear film. Oral omega-3 supplementation has been shown to improve nerve regeneration after injury to the cornea. Aim The aim of this work was to evaluate tear menisci parameters by AS-OCT in diagnosis of dry eye after LASIK procedure and evaluation of the role of oral omega-3 supplementation in the management of dry eye after LASIK. Patients and methods A prospective randomized study was performed on 50 participants who underwent LASIK procedure. These participants were further divided in two groups: the first group included 25 cases supplemented with omega-3 fatty acids, and the second group included 25 cases without omega-3 supplementation. The mean age of the studied patients with omega-3 administration was 33.2 ± 10.49 years, with a range from 19 to 45 years. Cases with any inflammatory pathology of the lid were excluded from the study. Results Upper tear meniscus height, upper tear meniscus depth, and upper tear meniscus area were statistically lower than lower tear meniscus height, lower tear meniscus depth, and lower tear meniscus area preoperatively and 1 day, 1 week, and 1 month postoperatively among the studied patients. Upper and lower tear menisci parameters were statistically higher inomega-3-treated group than control group preoperatively and at 1 day, 1 week, and 1 month postoperatively. Conclusion AS-OCT is considered a noninvasive approach to produce a tear meniscus image and a potential tool to diagnose dry eye after LASIK.

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