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Subject Area

Radiology and Imaging Sciences

Article Type

Original Study

Abstract

Objective The aim of this study was to evaluate the neutrophils-to-lymphocyte ratio (NLR) among patients with ischemic stroke and to determine the relationship between NLR and poststroke prognosis Background Inflammations play a role in the pathogenesis of cerebral infarction. Cytokines and adhesion molecules regulate the increased migration of leukocytes to the brain. Neutrophils are the first type of leukocytes to infiltrate ischemic brain (30 min of cerebral ischemia), peak earlier (days 1–3), and then decrease rapidly with time. Lymphocyte recruitment into the brain is involved in the later stages of ischemic brain injury. Patients and methods A retrospective study was done on 60 patients with ischemic stroke and 35 age-matched and sex-matched healthy controls. NLR was assessed from the patients' blood samples. Results The results were collected, tabulated, and statistically analyzed by IBM personal computer and statistical package SPSS, version 2, a P value of less than 0.05 was considered statistically significant. NLR among ischemic stroke patients was significantly higher than that of the control group. The optimal cutoff value of NLR for the prediction of primary unfavorable outcome was 2.05 with a sensitivity of 90% and a specificity of 96%. Conclusion NLR is a nonexpensive and easy marker for predicting stroke severity on admission, which is a primary unfavorable functional outcome.

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