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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives To evaluate the serum level of 8-hydroxy-2-deoxyguanosine (8-OHdG) in patients with acne vulgaris and also to detect relation between serum level of 8-OHdG and acne vulgaris severity. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles, characterized mainly by comedones. The precise mechanisms of acne are not known. Oxidative stress within the pilosebaceous unit are considered an important initiating step in the pathogenesis of acne. 8-OHdG is considered to be one of the main biomarkers of oxidative stress. Patients and methods This cross-sectional study was carried out on 75 patients with mild, moderate, and severe acne vulgaris, along with 15 age-matched and sex-matched healthy individuals. Acne severity was assessed by using the global acne score. Blood samples were taken for measuring serum 8-OHdG levels in patients and controls by using commercial enzyme-linked immunosorbent assay kit. Results The serum levels of 8-OHdG were significantly higher in patients with acne vulgaris when compared with healthy individuals (P = 0.005). A strong positive correlation between serum levels of 8-OHdG and acne severity was found (P < 0.001, r = 0.53). Conclusion Oxidative stress has an important role in acne pathogenesis represented by elevated 8-OHdG levels.

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