Tissue expression of endothelial selectin in patients with atopic dermatitis

Authors

Azza G. A. Farag, Menoufia University
Dalia R. A. Sharaky, Menoufia University
Eman N. El-Shafey, Menoufia University
Sawsan S. Allam, Ministry of HealthFollow

Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies. Background AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes. Patients and methods A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done. Results There were significant elevations in E-selectin cellular localization (P = 0.01) as well as dermal inflammatory infiltrates in AD cases than controls. Conclusion E-selectin participates in AD pathogenesis.

Recommended Citation

Farag, Azza G. A.; Sharaky, Dalia R. A.; El-Shafey, Eman N.; and Allam, Sawsan S. (2020) "Tissue expression of endothelial selectin in patients with atopic dermatitis," Menoufia Medical Journal: Vol. 33: Iss. 3, Article 59.
DOI: https://doi.org/10.4103/mmj.mmj_72_19