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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objectives To assess the level of kisspeptin in the serum of boys with constitutional delayed puberty (CDP) and to study its correlation with the main hormones of reproduction [follicle-stimulating hormone (FSH), testosterone, and prolactin). Background CDP is a common problem with a prevalence of 2–2.5% of population, with unclear etiopathogenesis. Patients and methods This study was done on 25 boys; aged 14–18 years and having CDP (Tanner's stages I, II, and III) as the patient group and another 25 boys age-matched with full pubertal manifestations (Tanner's stage V) as a control group with exclusion of delayed puberty due to other causes, for example; hypogonadotropic or hypergonadotropic hypogonadism and exclusion of any diseases, operations, or drugs that may affect the onset of puberty. Results The result showed that serum kisspeptin is much significantly lower in the CDP group compared with the control. Serum kisspeptin is positively correlated to both testosterone and FSH and have no relation with prolactin. There was no significant differences between chronological and bone age of the control group, while in the CDP group, bone age is significantly delayed compared with their chronological age as well as the bone age of the control group. Weight and height are significantly less in the CDP group than that of the control. Serum testosterone and FSH is significantly lower in CDP compared with the control group, while serum prolactin showed no significant differences between both groups. Conclusion Further studies on CDP on a larger number of patients with trial of kisspeptin drug as a line of treatment for such cases.

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