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Subject Area

Cardiology and Vascular Medicine

Article Type

Original Study

Abstract

Objective This study aimed to evaluate the total antioxidant capacity (TAC) as an aging marker in patients with Alzheimer disease (AD). Background AD is a neurodegenerative disorder that affects elderly and is the most common type of dementia. Reactive oxygen species is a major risk factor of Alzheimer. Oxidative stress, the most important factor in the pathogenesis of Alzheimer, occurs when reactive oxygen species and reactive nitrogen species increase and/or antioxidant defense system decreases. TAC is a marker of DNA oxidation. These data will explain pathogenesis and prevention and help in the treatment of AD. Patients and methods This study was carried on 90 individuals categorized into three groups: group 1 (patients group) included 30 patients with AD, group II (control matched group) included 30 age-matched and sex-matched apparently healthy participants, and group III (pregeriatric group) included 30 apparently healthy participants. Their age was between 30 and 60 years old. The determination of the TAC is performed calorimetrically by the reaction of antioxidants in the sample with a defined amount of exogenously provide hydrogen peroxide. Results There was a highly significant decrease in TAC in all studied group. Receiver operating characteristic curve for antioxidant to predict Alzheimer's cases versus control matched group showed that at a cutoff point of less than or equal to 1.16, it had a sensitivity of 73.33%, specificity of 83.33%, positive predictive value of 81.5% and negative predictive value of 75.8%. Conclusion Our results indicate a relation between oxidative stress and AD, indicating a possible role of these markers in diagnosis of AD.

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