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Subject Area

Community Medicine

Article Type

Original Study

Abstract

Objectives To assess left atrial function by speckle tracking in patients with heart failure (HF) with reduced ejection fraction and HF with preserved ejection fraction and correlate it with brain natriuretic peptide (BNP). Background HF is a clinical syndrome characterized by impaired structure and/or function of the heart, leading to dyspnea and fatigue at rest or with exertion. The pathophysiology of HF is complex, and there is no single etiological lesion. Patients and methods The study comprised 80 randomly selected persons presented to Cardiology Department of Menoufia University Hospitals, Egypt, from January to October 2016 to April 2018. They included 35 patients with Ejection fraction (EF) less than 50% Heart failure with reduced ejection fraction (HFrEF) (group I), 35 patients with Ejection fraction (EF) more than 50% Heart failure with preserved ejection fraction (HFpEF) (group II), and 10 normal individuals (control group), with typical signs and symptoms of HF and normal sinus rhythm. Results Patients with HF with reduced EF had significant increase in left ventricular volumes and left atrium (LA)volumes when compared with controls. All HF patients with reduced EF had a significant decrease in LA active emptying (volume, fraction)and LA passive emptying fraction, volume) when compared with controls. BNP had significantly higher values in HF patients with reduced EF compared with controls. Conclusion LA increased (volumes) and decreased (function), measured by strain and volumetric parameters in HF patients with reduced ejection fraction regarding controls. There was a significant increase in BNP in patients with HF with reduced ejection fraction and those with preserved ejection fraction compared with controls. The current study showed that BNP level was higher among HF groups (groups I and II) than among the controls (group III).

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