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Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Objective The aim was to evaluate the relationships between serum adiponectin level and lumbar bone mineral density (BMD) in osteoporotic postmenopausal women with or without type 2 diabetes mellitus. Background Adiponectin is a novel adipocytokine that could influence bone metabolism. Patients and methods This case–control study was conducted on 55 postmenopausal women selected from diabetic endocrinology inpatient and outpatient clinics. Patients were divided into three groups: osteoporotic group (group A), which included 20 nondiabetic osteoporotic postmenopausal women; diabetic osteoporotic group (group B), which included 20 type 2 diabetic osteoporotic postmenopausal women; and control group (group C), which included 15 nonosteoporotic, nondiabetic women postmenopausal. All patients were subjected to complete history, clinical examination, we measured and recorded the anthropometric measures, fasting blood sugar, hemoglobin A1c, serum calcium, serum phosphorus, parathyroid hormone, thyroid-stimulating hormone, erythrocyte sedimentation rate, C-reactive protein, serum adiponectin levels measured by ELISA, and lumbar spine BMD by dual-energy x-ray absorptiometry scan. Results In osteoporotic group (group A), serum adiponectin had a negative significant correlation with BMD (r=−0.45 and P = 0.04). The diabetic osteoporotic postmenopausal group (group B) showed the lowest concentration of serum adiponectin (μg/ml) compared with group A and the control. Lumbar BMD of group B was significantly higher than that of group A. Conclusion Serum adiponectin is associated with lumber BMD in osteoporotic postmenopausal women, which suggests that serum adiponectin was involved in bone metabolism.

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