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Subject Area

Clinical Pharmacology

Article Type

Original Study

Abstract

Objectives To elucidate the correlation between serum magnesium (Mg) and intact parathormone hormone (iPTH) levels and between serum Mg and cardiac calcification in chronic hemodialysis patients. Background Patients with chronic kidney disease (CKD) have various complications, one of which is mineral and bone disorder. iPTH is a major player in CKD-mineral and bone disorder and it may have a relation with Mg. Also, lower serum Mg levels may BE associated with cardiac calcification in CKD. Patients and methods Medical charts of 50 hemodialysis patients were reviewed retrospectively. Demographic and laboratory analyses were recorded. Echocardiographic findings were collected, with stressing on valve calcification (VC). We investigated their serum Mg levels and the correlation between iPTH and serum Mg levels, and other clinical parameters. Results Regarding dividing patients into two groups according to Mg level: iPTH, abdominal aortic radiography calcification, carotid intima thickness, BMI, age, and VC were lower in patients with high Mg than other patients (306.36 ± 69.53 vs. 365.36 ± 116.72 pg/ml; P = 0.042) in multiple regression analysis according to the serum Mg level. the iPTH level was an independent variable after adjustment for other factors. VC was found in 31 (62.2%) patients and significantly increased with older age (P = 0.018). Also, aortic calcification, lower serum Mg, and high low-density lipoprotein levels were found in patients with VC. Conclusion The results of this study indicate a significant negative correlation between serum Mg and iPTH in regular hemodialysis patients, and it was an independent factor among other significant parameters according to serum Mg levels. Also, low Mg level is frequent in regular hemodialysis patients with VC.

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