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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective In this study, the authors assessed the prognostic value of Glasgow prognostic score (GPS) in overall survival (OS) and progression-free survival. Background Inflammation plays an important role in the pathogenesis of ovarian cancer. The GPS is an inflammation-based prognostic score composed of C-reactive protein and albumin. Patients and methods A prospective study was conducted in the Department of Clinical Oncology, Menoufia University, between June 2016 and December 2018. The authors analyzed the clinicopathological characteristics and pretreatment C-reactive protein and serum albumin levels of 57 patients with epithelial ovarian cancer. Time to treatment failure and OS were determined using Kaplan–Meier method. Results High GPS was significantly associated with age, performance status, elevated Ca125 level, advanced stage, ascites, size of residual tumor after the debulking surgery, and platinum sensitivity (P < 0.001). In addition, patients with higher GPS had shorter progression-free survival (P < 0.001) and OS (P = 0.107). However, multivariate analysis revealed that GPS is not an independent prognostic factor in those group of patients. Conclusion High GPS is a poor prognostic factor in patients with epithelial ovarian cancer.

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