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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objectives The purpose of this study was to evaluate the changes in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in idiopathic intracranial hypertension or pseudotumor cerebri (PTC). Patients and methods This cross-sectional comparative study involved 50 patients with PTC (group I) and 50 age-matched and sex-matched normal persons as controls (group II). Retinal nerve fiber thickness is measured using OCT for all studied population and then recorded and collected to be statistically analyzed. Results Visual acuity and best-corrected visual acuity were measured in both groups. Comparison between both groups shows a statistically highly significant difference (P < 0.01). Both groups showed a statistically highly significant difference between both groups (P < 0.01) regarding intraocular pressure. Thickness of the RNFL in the studied groups according to OCT measures showed a statistically very highly significant difference between both groups (P < 0.001). Conclusion RNFL thickness measurements can provide important information regarding retinal axonal loss in patients with papilledema from PTC. Although axonal loss was documented in the chronic phase of papilledema, our findings, to be confirmed in future prospective studies, suggest a possible use of OCT during the treatment of PTC syndrome.

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