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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective To assess macular thickness changes posttrabeculectomy with and without mitomycin C (MMC) and to find the association between these postoperative changes and intraocular pressure (IOP). Patients and methods This study included 40 eyes of 31 patients who underwent trabeculectomy. It was done at a private eye center in Alexandria from December 2017 to September 2018. Study patients were stratified into two groups (20 each): trabeculectomy with MMC and trabeculectomy without MMC. Results The mean (±SD) (IOP) reduced from 29.48 (±3.57) mmHg before trabeculectomy to 19.05 (±2.86) mmHg 1 week (P < 0.001) and to 15.38 (±3.05) mmHg 6 months (P < 0.001) after the operation. One week postoperatively, the mean macular thickness increased from 289.98 (±18.11) μm to 296.81 (±17.15) μm (P < 0.001); macular thickening was significant in all macular subfields. Mean macular thickness correlated positively with postoperative IOP reduction (P < 0.005). Significant correlation was found at central (P < 0.001), superior inner (P = 0.014), inferior outer (P = 0.001), and nasal outer (P = 0.023) macular subfields. Six months later, macular thickening remained significant only at the central and inner nasal macular subfields (P2=0.007, P2 <0.001), respectively, and there was no significant correlation between IOP reduction and macular thickness at the same time. MMC had no effect on these changes. Conclusion Trabeculectomy may increase macular thickness in the early postoperative period. However, MMC has no effect despite its possible toxic effects on the retina.

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