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Subject Area

Physical Medicine, Rheumatology and Rehabilitation

Article Type

Original Study

Abstract

Objective To compare the effect of oxytocin (OXT) versus human chorionic gonadotropin (HCG) versus combination of both on ovulation triggering. Background HCG has been used as an alternative to luteinizing hormone for triggering ovulation. HCG has high cost and needs close monitoring. In this study, we try to clarify the possible role of OXT as an alternative to HCG for triggering ovulation. Patients and methods A randomized controlled clinical trial was carried out on 108 infertile women with anovulation or oligo-ovulation; each of them received 100-mg clomiphene citrate from the second to the sixth day of the cycle and were monitored by transvaginal sonography. They were randomly divided into four groups: group 1 received 10 000 IU HCG, group 2 received 10 IU OXT, group 3 received both of them, and group 4 did not receive any triggering medication. Results There was significant difference regarding ovulation between studied groups and control (33.3%). There was no significant difference in ovulation between HCG group versus OXT group (χ2 = 0.83,P= 0.362), HCG group versus combination group (χ2 = 0.11,P= 0.735) and OXT group versus combination group (χ2 = 1.54,P= 0.214). There were statistically significant high plasma progesterone levels between studied groups and control (P = 0.001). There was significant difference in pain sensation between HCG group versus OXT and combination groups (P = 0.001). Conclusion OXT is suggested to be used alone or in combination with HCG for triggering ovulation.

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