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Subject Area

Family Medicine

Article Type

Original Study

Abstract

Objectives To find if there is a role of insulin-like growth factor-1 receptor (IGF-1R) in female androgenetic alopecia (FAGA). Background Patterned hair loss continues to be one of the most important hair problems affecting both men and women. It is the most common form of alopecia, affecting up to 50% of women in the course of their lives. Insulin-like growth factor-1 (IGF-1) is one of the most potent natural activators of the protein kinase B signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programed cell death. IGF-1 is a physiological regulator of hair growth cycle. It helps maintain the anagen stage. Patients and methods This case–control study was conducted on 20 FAGA patients and 10 age-matched healthy female patients with no androgenetic alopecia as control. They were chosen from Dermatology Clinic at Menoufia University Hospital between April 2017 to April 2018.They were subjected to history taking and complete medical examination. Punch biopsies were taken, and by immunohistochemical staining, the degree of intensity and the percentage of IGF-1R were determined. Results The degree of intensity and percentage of IGF-1R in the diseased patients showed statistically significant difference from the normal patients (P = 0.001). There was no significant correlation between IGF-1R expression and age (P = 0.120) and menstrual history (P = 0.189), respectively. Conclusion On the basis of the results, it could be concluded that IGF-1R markedly diminished in FAGA.

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