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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective To evaluate the plasma levels of nitrate in patients with thalassemia and sickle cell anemia. Background The bioavailability of nitric oxide (NO) in patients with thalassemia and sickle cell anemia is decreased due to chronic hemolysis and consequently endothelial dysfunction that can result in the development of certain complications in both the diseases. Plasma concentration of nitrate is considered as an important reservoir for NO whose level can be a landmark for the bioavailability of NO. Patients and methods Our case–control study involved 93 patients aged 10–18 years divided into two groups, a case group composed of 73 patients; 44 patients with thalassemia and 29 patients with sickle cell anemia and 20 age-matched apparently healthy persons as a control group. Plasma levels of nitrate were evaluated by enzyme-linked immunosorbent assay. Results The results of our study have revealed that the plasma levels of nitrate are significantly lower in the case group than the control group. Conclusion An evidence of decreased NO bioavailability proved by a decreased plasma nitrate is present in patients with thalassemia and sickle cell anemia that can be implicated for multiple complications in both the diseases.

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