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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective To evaluate the effects of bone marrow mononuclear cells (BMMCs) transplantation in rats with toxic acute liver damage induced by carbon tetrachloride (CCL4). Background Acute liver failure is a severe syndrome which need rapid and effective treatment. The present study was to examine whether BMMCs might be useful in the management of acute liver failure in an animal model or not. Materials and methods BMMCs were obtained from 8 to 10 ml of human bone marrow (10 × 106 cells) injected into the portal vein of rats 24 h (n = 32) after liver damage with CCL4. Control group (n = 32) was injected with only saline in CCL4-treated animals. Transaminases and survival were measured at 24 h, 72 h, 1, 2, 3, 4 weeks. Liver histology was observed 2 and 4 weeks after injury. Results Transplanted BMMCs were found to populate the damaged liver. Animals that received BMMCs also showed a trend toward improved liver enzymes as well enhanced survival rates, relative to the control. Conclusion This study results indicate that BMMC transplantation has potential as a new therapeutic option for acute liver disease and suggest that these cells may contribute to hepatic recovery.

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