•  
  •  
 

Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective The aim was to assess whether uterine artery Doppler indices can predict significant causes of uterine bleeding in patients with perimenopausal bleeding or not. Background Treatment of abnormal uterine bleeding needs easy diagnostic procedure, for determining the etiological factor of disease. The abnormal uterine bleeding is more common in the perimenopausal than in the postmenopausal women, and it is a sign of endometrial proliferative or hyperplastic changes. Patients and methods This prospective observational study was conducted on 106 women with perimenopausal bleeding [who were subdivided into two groups, one with nonsignificant causes (52 patients) and the other with significant causes (54 patients)] and 50 healthy controls, with transvaginal ultrasonic color Doppler study performed before endometrial sampling with pipelle in those with perimenopausal bleeding. Test characteristics of uterine artery pulsatility index and resistance index for prediction of significant causes of bleeding were the main outcome measures. Results Uterine artery pulsatility index at cutoff value of 1.82 with area under the curve of 0.834, sensitivity of 70.8%, specificity of 92%, positive predictive value of 94.9%, negative predictive value of 69.9%, and accuracy of 78%, whereas uterine artery resistance index at cutoff value of 0.575 with area under the curve of. 998, sensitivity of 96.2%, specificity of 100%, positive predictive value of 100%, negative predictive value of 92.6%, and accuracy of 97% were predictive of significant causes of perimenopausal bleeding. Conclusion Uterine artery Doppler is a simple, readily available and noninvasive tool that could be beneficial in conjunction with endometrial sampling to detect significant causes of perimenopausal bleeding.

Download

Share

COinS