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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective The aim was to study the effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome (PCOS). Background PCOS is an endocrine disorder that affects mostly women of reproductive age. Metformin has positive biochemical effects in PCOS patients' therapy. Patients and methods A case–control study was conducted on 98 women who were divided into: group I which included 49 infertile women with PCOS and group II which included 49 fertile women without PCOS. All patients attended the Obstetrics and Gynecology Outpatient Clinic at Menoufia University Hospitals and Tala General Hospital, Egypt, from April to November 2017. Detailed history, clinical examination, routine baseline investigations, and Doppler flow were done. Results There was a statistically significant difference between the studied groups regarding weight, BMI, follicle-stimulating hormone, and Doppler post-treatment resistance and pulsatility indices (left, right). There was a statistically highly significant difference (P ≤ 0.001) regarding Doppler posttreatment resistance and pulsatility indices (left, right) before and after metformin treatment. Also, a nonsignificant correlation was recorded between Doppler resistance and pulsatility indices (left, right) and age, weight, BMI, follicle-stimulating hormone (mIU/ml), and luteinizing hormone (mIU/ml) in the patients group after metformin treatment. Conclusion Metformin has a beneficial effect in women with PCOS via correcting the ovarian stromal blood flow and hormonal profile. Ovarian stromal Doppler markers such as the resistance index and pulsatility index can help us to follow up the therapy of PCOS patients.

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