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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objectives The aim of this study was to determine the effect of local injection of platelet-rich plasma (PRP) in patients with mild and moderate knee osteoarthritis (OA) and its effect on pain in comparison to corticosteroid injection. Background OA is one of the most prevalent chronic musculoskeletal diseases worldwide. The use of PRP appeared in the last years for the management of symptoms of knee OA. Patients and methods This study included 50 patients with knee OA. Our patients were divided to two groups: a group of 25 patients who were injected intra-articularly with about 3–4 ml of PRP and another of 25 patients who were injected intra-articularly with triamcinolone acetate for one affected knee. We measure and assess all patients by Western Ontario and McMaster Universities Osteoarthritis Index and visual analog score – pain questionnaires before injection and after 1 and 3 months of injection. Results There was a highly statistically significant difference between preinjection and postinjection after 1 month with more decrease in postinjection (P < 0.001) and highly statistically significant difference between preinjection and follow-up injection in Western Ontario and McMaster Universities Osteoarthritis Index score with more decrease in follow-up (P < 0.001). Also there was a highly significant decrease in visual analog score scale readings in postinjection (P < 0.001) and follow-up after 3 months of injection (P < 0.001). Conclusion Intra-articular injection PRP is an effective method for the treatment of knee OA. Also, PRP intra-articular injection is more effective than intra-articular injection of corticosteroid.

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