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Subject Area

Clinical Pathology

Article Type

Review

Abstract

Objective The aim of this study was to evaluate the role of feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3) in acute myeloblastic leukemia (AML). Background AML is the most common acute leukemia affecting adults, and its incidence increases with age. FLT3 belongs to the class III receptor kinase family, which plays an essential role in hematopoiesis, driving differentiation of early myeloid and lymphoid lineages. Data sources Medline databases (PubMed, Medscape, Science Direct) and all materials available in the Internet from 1996 to 2017. Study selection The initial search yielded 107 articles, of which 20 fulfilled the inclusion criteria. The articles studied the relation between FLT3 and AML. Data extraction Midline searches with the keywords 'acute myeloblastic leukemia, Feline McDonough Sarcoma like tyrosine kinase, FLT3' in the title of the papers; extraction was performed, including assessment of the quality and validity of papers that fulfilled the previous criteria of FLT3 expression in AML. Data synthesis Each study was reviewed independently; the data obtained were rebuilt in a new language according to the needs of the researcher and categorized into topics throughout the article. Comparisons were made by structured reviews, with the results tabulated. Findings The studies indicated that FLT3 is significantly increased in patients with AML. Conclusion FLT3 overexpression was found in patients with AML and correlated with relapsed cases, worse survival, and poor outcome. This indicated that FLT3 overexpression can be used as a poor prognostic predictor for AML.

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