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Subject Area

Ophthalmology

Article Type

Original Study

Abstract

Objective The objective of this study was to assess visfatin and resistin levels in children with β-thalassemia major and intermedia. Background β-Thalassemia represents a major public health problem in Egypt. Adipocytokines are bioactive mediators released from the adipose tissue including adipocytes and other cells present within fat tissues. Patients and methods This study was conducted on 70 patients with β-thalassemia diagnosed by both clinical and laboratory criteria. They were divided into two groups: group I included 50 patients with β-thalassemia major and group II consisted of 20 patients with β-thalassemia intermedia. Moreover, 20 healthy individuals were included as a control group. All the participants were included from February 2016 to February 2017. Full history, routine physical examination, and special investigations were taken. Results BMI (kg/m2) was significantly lower in patients with β-thalassemia than control group, and it was higher in β-thalassemia intermedia group than β-thalassemia major group. Lipid profile and serum resistin and visfatin levels were significantly higher in patients with β-thalassemia than control group. Resistin was positively correlated with total leukocyte count, ferritin, urea, serum glutamic pyruvic transaminase, and serum glutamic oxaloacetic transaminase and negatively correlated with BMI and hemoglobin. Serum visfatin was positively correlated with total leukocyte count, urea, serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, lipid profile, and glucose and negatively correlated with BMI and hemoglobin. Conclusion The adipocytokines (resistin and visfatin) were significantly higher in patients with β-thalassemia (major and intermedia) than control group. The measurement of these adipocytokines may be helpful in differentiating the degree of inflammation. Moreover, a novel association was found between the increasing concentrations of proinflammatory adipocytokines (resistin and visfatin) and the severity of β-thalassemia types.

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