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Subject Area

Ophthalmology

Article Type

Original Study

Abstract

Objective The present study aimed at evaluating microvascular density (MVD) in involved and uninvolved skin of patients with psoriasis. Background Psoriasis is a chronic inflammation skin disease characterized by accelerated proliferation, abnormal differentiation, and increased angiogenesis. The angiogenesis is related to many factors in the pathogenesis of psoriasis. The assessment of angiogenesis using cluster of differentiation 34 can help more understanding of psoriasis pathology. Patients and methods This study was carried out on biopsies of involved and uninvolved skin from 40 patients with psoriasis and 40 apparently healthy volunteers as a control group. Biopsies were processed for immunostaining procedure in the pathology department. Results After assessment of the MVD highlighted by cluster of differentiation 34 immune-staining, the skin of psoriatic cases (involved and uninvolved) was of significantly higher MVD values in comparison with normal skin of control group (P < 0.001). Additionally, the involved psoriatic skin showed significantly higher MVD values compared with uninvolved skin (P < 0.001). Conclusion Angiogenesis has a role in the pathogenesis of psoriasis, as it was accelerated in both involved and uninvolved skin.

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