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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective To evaluate left ventricular function using speckle tracking echocardiography (STE) in pediatric patients with end-stage renal disease (ESRD) with preserved left ventricular ejection fraction. Background ESRD is considered a leading cause of cardiovascular morbidity and mortality in pediatric patients. With the help of newer echocardiographic modalities such as two-dimensional (2D) STE, an early diagnosis of the cardiac involvement through the detection of subclinical myocardial dysfunction might be possible in pediatric patients with ESRD. Patients and methods This study was carried out on 35 children under regular hemodialysis for at least 3 days weekly owing to ESRD who were followed up at Menoufia University Hospital Nephrology Unit and 27 controls who were recruited from the outpatient clinic. They were subjected to detailed history taking; general and local clinical examination; laboratory investigations, such as complete blood count and serum creatinine level; and 2D STE. Results There was a highly statistically significant difference between cases and controls regarding global strain of four-chamber, two-chamber, and three-chamber views. Moreover, there was a highly statistically significant difference between cases and controls regarding left ventricular mass index, which correlated with global strain but did not correlate with left ventricular ejection fraction. Conclusion 2D STE helps in early diagnosis of the cardiac involvement in pediatric patients with ESRD who have normal ejection fraction through the detection of subclinical myocardial dysfunction.

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