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Subject Area

Clinical Pathology

Article Type

Review

Abstract

Objective The aim of this study was to study the role of osteopontin (OPN) in dermatological diseases through a meta-analysis study. Data sources Previous literatures, reviews, and studies as well as medical websites (PubMed, Medscape and Science Direct), all material available in the internet from 2014 to 2017, and scientific journals databases were searched from the start date of each database. Study selection The initial search presented 10 articles of which five met the inclusion criteria. Selection was done by supervisors for studying the role of OPN in dermatological diseases. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Data synthesis Comparisons were made by a structured review with the results tabulated. Findings In total five potentially relevant publications were included; all were human studies. The studies show an elevated level of OPN in some dermatological diseases such as allergic contact dermatitis, alopecia areata, psoriasis, sarcoidosis, and systemic lupus erythematosus in comparison to the controls. Conclusion As OPN was elevated among allergic contact dermatitis, alopecia areata, psoriasis, sarcoidosis, and systemic lupus erythematosus patients, it may play a role in the pathogenesis of such diseases.

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