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Subject Area

Pediatrics

Article Type

Review

Abstract

Objective The objective of this study was to evaluate the effect of vitamin E supplementation in the treatment of indirect hyperbilirubinemia in neonates receiving phototherapy. Background Hyperbilirubinemia is a common neonatal problem. Phototherapy is the primary treatment in neonates with indirect hyperbilirubinemia. Patients and methods This randomized controlled clinical trial was conducted on 150 full-term neonates with indirect hyperbilirubinemia, received phototherapy in the neonatal ICU of Menoufia University Hospital. They were randomly divided into three groups: (a) case group (n = 50) who received 25 mg/kg/day oral vitamin E with phototherapy, (b) case group (n = 50) who received 50 mg/kg/day oral vitamin E with phototherapy, and (c) control group (n = 50) who received only phototherapy. Total serum bilirubin (TSB) levels were measured every day until cessation of phototherapy. Results There was a highly significant difference in the duration of hospital stay of the studied groups. There was no significant difference in TSB on admission, but there was a highly significant difference in TSB at discharge of the studied groups. There was a highly significant difference in bilirubin decline of the studied groups, groups II and I and groups I and III, but no significant difference between groups II and III. There was no correlation between age and body weight in bilirubin decline in all groups. There was no significant difference in bilirubin decline with regard to sex in all groups. Conclusion The addition of oral vitamin E 25 mg/kg/day to phototherapy in the treatment of indirect hyperbilirubinemia is better than oral vitamin E 50 mg/kg/day or phototherapy alone.

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