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Subject Area

Pediatrics

Article Type

Review

Abstract

Objective The aim was to evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of gaping and chronic wounds. Background Nonhealing ulcers are a major health problem with high cost in terms of human and material resources. Application of autologous PRP has been a major breakthrough for the treatment of nonhealing ulcers, as it is an easy and cost-effective method and provides the necessary growth factors that enhance wound healing. Patients and methods A study was performed on 28 patients with nonhealing ulcers of various etiologies. Overall, 19 patients were treated with PRP at weekly intervals for a maximum of seven treatments and nine patients were treated with saline gauze dressings on alternative days. At the end of the 7, 14, 21, and 28-day periods, reduction in size of the ulcers (area and volume) was assessed and followed up till the healing completed, and the patients were followed up for a period of 12 weeks after treatment. Results The mean age ± SD of the patients was 39.68 ± 12.11 years. Of 19 ulcers in study group, there were two venous ulcers, nine traumatic ulcers, five pressure ulcers, and three diabetic ulcers. The mean ± SD duration of healing of the ulcers was 49.84 ± 22.23 days in study group and 108.67 ± 5.64 days in control group (P < 0.001). Conclusion Conventional therapies do not provide satisfactory healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors essential for the healing process. PRP is a safe, affordable, biocompatible, and simple office-based procedure for the treatment of nonhealing ulcers.

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