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Subject Area

Urology

Article Type

Original Study

Abstract

Objective The aim was to assess the changes in the lipid profile of children with end-stage renal disease (ESRD) on chronic hemodialysis after administration of high-dose omega-3. Background Children with ESRD on chronic hemodialysis have many factors that increase their risk of cardiovascular disease (CVD) such as dyslipidemia, hypertension, and physical inactivity. CVD is considered to be one of the major causes of morbidity and mortality in these children. Some studies were done on the omega-3 effects on lipid profile, the results of which were promising that omega-3 can improve the lipid profile which has a good impact on saving the ESRD patients from dyslipidemia and CVD. Patients and methods This interventional prospective study had included 26 children with ESRD on chronic hemodialysis in the Pediatric Hemodialysis Unit at the Menoufia University Hospital, who were treated daily with a high dose of omega-3 (2000 mg) for 3 months (from January to April 2016) and lipid profile was done and compared before and after omega-3 supplementation. Results After supplementation of high-dose omega-3, there were statistically highly significant decrease (P < 0.001) in total cholesterol by 30%, triglyceride by 32%, and low-density lipoprotein by 23%, together with a statistically highly significant increase (P < 0.001) in high-density lipoprotein by 26%. Conclusion The use of high-dose omega-3 had caused significant improvement in the lipid profile of ESRD children on chronic hemodialysis, so supplementary omega-3 may be a suitable treatment for these patients.

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