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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objective The objective of this study was to clarify the possible role of calgranulin C (Cal C) protein in psoriasis and to correlate its level with disease severity. Background Psoriasis is a chronic inflammatory disease that affects 2–3% of world population. Cal C protein has been implicated in the pathogenesis of various inflammatory diseases. The relation between psoriasis and Cal C protein is discussed in this study. Patients and methods This case–control study was conducted on 25 patients with psoriasis vulgaris and 15 age-matched and sex-matched healthy individuals. All patients were subjected to history taking and complete medical examination. Serum levels of Cal C protein were measured by enzyme-linked immunosorbent assay technique. Serum levels of Cal C protein were statistically analyzed in relation to Psoriasis Area and Severity Index score. Results High serum level of Cal C protein among cases showed highly significant difference compared with control group (P < 0.001). Moreover, there was a highly significant difference between moderate and severe cases (P < 0.001 for both). There was a significant positive correlation between Cal C protein and Psoriasis Area and Severity Index score (P = 0.01). Conclusion Cal C protein was higher in patients with plaque psoriasis than normal population, so it may play a significant role in the pathogenesis of psoriasis and may provide important clues to assist in the development of new therapeutic strategies for patients with psoriasis and also may be used as a marker of psoriasis severity.

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