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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objective The aim of this paper was to assess the effect of successful eradication of Helicobacter pylori (H. pylori) infection on the activity of chronic idiopathic urticaria (CIU) in patients with CIU infected with H. pylori. Materials and methods Medline databases including PubMed, Medscape, ScienceDirect, and EMF-Portal and all materials available in the Internet from 2005 to 2016 were searched. The initial search presented 28 articles, of which six met the inclusion criteria. The articles studied the relation between CIU and H. pylori infection and the effect of H. pylori eradication on the disease activity. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made by structured review, with the results tabulated. Findings In total, six potentially relevant publications were included, and they were all human studies. Several studies showed high prevalence of H. pylori infection in patients with CIU, with clinical improvement of the disease activity after H. pylori eradication, whereas other studies concluded that there is no evidence that eradication of H. pylori improves the outcome in patients with CIU. The high rate of spontaneous remission and the coexistence of multiple foci will always obscure the evaluation of any specific antimicrobial therapy. Conclusion We found that H. pylori may play a role in the pathogenesis of CIU, and H. pylori eradication therapy must be tried for positive cases with CIU.

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