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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objectives The aim of this study was to assess serum vitamin D level in women with female pattern hair loss (FPHL) to approve its relation in this disorder. Background FPHL is the main cause of diffuse hair loss in adult women and majorly affects patient's personal satisfaction. FPHL is the preferred term for androgenetic alopecia in women as the relation between androgens and this illness is not proved. Androgen excess has not been demonstrated in FPHL. The connection between serum 25-hydroxy vitamin D and FPHL has not been considered altogether. Patients and methods In this case–control study, we studied serum vitamin D level concentration among 31 FPHL patients aged 20–40 years in comparison with 31 healthy female controls matched for age, skin phototype, socioeconomic level, and outdoor exposure. Measurements were conducted by enzyme-linked immunosorbent assay. The study was conducted within a 4-month period, from July to October 2016. Results The mean serum vitamin D level was significantly lower in FPHL patients (18 ± 7.57 ng/ml) than in controls (35.09 ± 15.39 ng/ml; P < 0.001). This result supports the suggestion that the decreased hair density present in patients with FPHL may possibly be associated with decreased levels of mean serum vitamin D levels. Significant difference was found between the three Ludwig's degrees regarding the mean serum vitamin D level (20.04 ± 7.49, 17.77 ± 6.98, and 8.43 ± 0.75 ng/ml, respectively) between degrees I and III and between degrees II and III. Conclusion The lack or inadequacy vitamin D may assume a conceivable part in the pathogenesis of FPHL.

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