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Subject Area

Otorhinolaryngology

Article Type

Original Study

Abstract

Objective The objective was to research the value of platelet to lymphocyte ratio (PLR) as an indicator of severity of coronary atherosclerosis. Background Cardiovascular disease is the commonest cause of death worldwide. The process of coronary atherosclerosis is greatly dependent on several factors. New inflammatory markers were believed to be valuable as indicators of severity of coronary atherosclerosis. Patients and methods We conducted a randomized prospective observational study in our Coronary Intervention Unit, Menoufia University hospital. One hundred and thirty patients qualified for elective coronary angiography were arranged into three groups based on their Gensini score. Group I patients with normal coronary angiography, group II patients with mild atherosclerotic coronary disease, and group III included patients with severe atherosclerotic coronary disease. Results There was a significant positive correlation between PLR and severity of coronary atherosclerosis estimated by Gensini score. Regarding group I, the mean PLR value is 102.8 whereas in group II, the mean PLR value is 114.98 and in group III, the mean PLR value is 141, providing a cut-off value of PLR 126.5 that predicts severe coronary atherosclerosis. Conclusion PLR is a powerful marker for the prediction of severity of coronary atherosclerosis and should be widely used for risk stratification of ischemic patients. Moreover, PLR should be considered when choosing the management strategy of such patients either conservatively or interventionally.

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