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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective The aim of this study was to assess the effect of sildenafil citrate versus nifedipine in improving uterine and endometrial arterial blood flow in patients suffering from recurrent unexplained pregnancy loss. Background Recurrent pregnancy loss is unexplained in 50% of cases. Therefore, the use of sildenafil citrate and other new drugs such as nifedipine may prevent miscarriages. Patients and methods The present study included a control group of 20 normal fertile women with at least one live birth, and two groups of 20 patients each with recurrent unexplained miscarriages. Participants were subjected to full history taking, clinical examination, ultrasonography, and transvaginal color Doppler test. Blood flow assessments were performed two times, before and after intervention by the same operator, to measure maximum endometrial thickness and uterine arterial blood flow parameters including systolic/diastolic blood pressure ratio, pulsatility index, and resistance index. Results Sildenafil citrate improves endometrial thickness and uterine artery blood flow indexes significantly compared with nifedipine. Conclusion Sildenafil citrate improves endometrial thickness and uterine arterial blood flow parameters including systolic/diastolic ratio, pulsatility index, and resistance index significantly compared with nifedipine.

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