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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objectives To perform a systematic review of the different categories of sepsis biomarkers including the new promising biomarkers and their role in diagnosis and prognosis of sepsis. Data sources Data were obtained from Medline databases (PubMed, Medscape, and Science Direct) and from materials available on the network from 2003 to April 2017. Study selection The initial search presented 30 articles. The research studies that met the inclusion criteria were 10 articles. All articles studied the role of biomarkers in diagnosis and prognosis of sepsis. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls mentioned, adequate information provided, and assessment measures defined. Data synthesis Comparisons were made by structured review with the results tabulated. Results The use of combined biomarkers can be more efficient than using a single biomarker in diagnosis and prognosis of sepsis. Conclusion Biomarkers play a vital role for early diagnosis of sepsis, to predict outcome, and to guide choice of antibiotic therapy. In these modern times, clinicians encounter the laboratory results on a daily basis. Therefore, proper interpretation and wise use of biomarkers are necessary. Combination approaches of biomarkers with new techniques have shown promising results and need to be further evaluated.

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