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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objectives The objective of this study was to evaluate morphologic and response evaluation criteria in solid tumors (RECIST) criteria in gastrointestinal tract (GIT) liver metastases patients as regards tumor marker and clinical response of patients. Background To evaluate morphological response criteria which detect tumor density changes on contrast enhanced computed tomography (CECT) in GIT liver metastases patients. These criteria will help to detect response to treatment by chemotherapy early before tumor size changes. Patients and methods We included in this study 40 patients already diagnosed with GIT liver metastases by physical examination, tumor marker assessment, and CECT. The patients received three to six cycles of chemotherapy followed by repeated physical examination, CECT, and tumor marker assessment. The lesions in the liver were then evaluated by RECIST and response criteria depending on morphology. Results There is a significant statistical relationship between morphological response and tumor marker response of patients (P = 0.002). However, the relationship between morphological response and clinical response is not statistically significant (P = 0.087). There is no significant statistical relationship between morphological response and RECIST (P = 0.281). Conclusion Morphologic criteria had significant statistical association with tumor marker response in patients with GIT liver metastases treated by different types of chemotherapy.

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