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Subject Area

General Surgery

Article Type

Original Study

Abstract

Objective The aim of this work was to study paroxonase 1-L55M gene polymorphisms in Behcet's disease (BD) and its relation to clinical manifestations. Background BD is a type of vasculitis characterized by recurrent orogenital ulcers, relapsing uveitis, and skin, articular, vascular, neurologic, and gastrointestinal manifestations. Genetic, environmental, and immunological factors are involved in its pathogenesis. Paraoxonase is thought to play an important role in the protection of low-density lipoprotein and high-density lipoprotein particles from oxidation. Lipid peroxidation and free oxygen radicals are believed to play a role in BD pathogenesis. Patients and methods In the current study, we examined 40 BD patients (group II). The diagnosis of BD was made according to the International Study Group Criteria of Behcet's Disease. We included 40 healthy adults as controls (group I). All participants were subjected to thorough history taking, physical examination, and laboratory investigations, including serum lipid profile (total cholesterol, triglycerides, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol) and paroxonase 1-L55M gene study using PCR. Results BD shows male predominance with a male:female ratio of 2.1:1. Oral and genital ulcers were the most common presentation and were present in almost all patients, followed by vascular, skin, central nervous system, and articular manifestations. There were no significant statistical differences between BD patients and the control group as regards PON1 genotype and allele frequencies. Conclusion PON1 L55M gene polymorphism is not associated with an increased risk for BD or its clinical manifestations.

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