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Subject Area

Anesthesiology and Intensive Care

Article Type

Original Study

Abstract

Objective The aim of this study was to investigate the correlation between serum alkaline phosphatase (ALP) levels and the severity of coronary artery disease (CAD) by assessing the Gensini score. Background The serum ALP level has been shown to be a prognostic factor in myocardial infarction and peripheral vascular disease by its promoting effect on vascular calcification. Patients and methods A total of 200 patients with stable angina pectoris were evaluated retrospectively. Upon admission, their ALP levels were measured with automated AU480 analyzer using kinetic rate method, and were evaluated according to Gensini score. Results The mean ALP level was 60 ± 21.858, ranging from 29 to 110 U/l, and there were 95 (47.50%) patients with low normal level (<63 IU/l), 75 (37.50%) patients with midrange level (63–78 IU/l), and 30 (15%) patients with high normal level (>78 IU/l). The mean Gensini score was 20.7 ± 21.8; 31 (15.50%) patients had a score of 0, 64 (32%) patients had mild CAD with a score ranging from 1 to 15, 75 (37.5%) patients had moderate CAD with a score ranging from 16 to 30, and 30 (15%) patients had severe CAD with a score more than 30. The advanced CAD group included more patients with diabetes mellitus and hypertension. Regression analysis showed a significant correlation between increased levels of serum ALP and advanced CAD in the multivariate model (χ2 = 372.434) (P < 0.001). Conclusion There was a significant correlation between serum ALP and severity of CAD according to Gensini score.

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