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Article Type

Original Study

Abstract

Objective The aim was to study the effect of metabolic syndrome (MS) on the severity of knee osteoarthritis (OA), as well as its association with generalized OA. Background Knee OA is a major cause of disability. Studies suggested that metabolic factors may have a negative effect on cartilage and may play a role in the pathogenesis of OA. Patients and methods A total of 60 patients with primary knee OA were divided into two groups: group I included patients with knee OA and MS and group II included patients with knee OA and without MS. Both groups were matched regarding age, disease duration, and MS (BMI). All were subjected to demographic data, blood pressure measurement, waist circumference, BMI, laboratory investigations, knees and hands radiograph, disease severity assessment by Lequesne functional index, and radiological Kellgren and Lawrence score. Results Group I patients were significantly more affected with varus deformity, flexion deformity, and tenderness over knee joint line and hand OA than group II patients. Radiologic findings revealed higher grades of Kellgren and Lawrence score grading system in group I patients than group II. The patellofemoral OA showed significantly higher mean in group I than in group II. The total functional score of Lequesne for knee OA showed significantly higher mean in group I (P < 0.001). Conclusion MS in patients with knee OA is associated with more severe clinical signs, progressive radiological damage, severe grades of functional disability, and more frequent affection with generalized OA in comparison with patients with OA without MS.

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